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《环境科学与工程前沿(英文)》 2022年 第16卷 第2期 doi: 10.1007/s11783-021-1453-z
• ZnO-NP disrupted metabolic/catabolic balance of bacteria by affecting DHA activity.
关键词: Granular sludge Biotoxicity Reactive oxygen species Extracellular polymeric substances
NADPH oxidase and reactive oxygen species as signaling molecules in carcinogenesis
Gang WANG
《医学前沿(英文)》 2009年 第3卷 第1期 页码 1-7 doi: 10.1007/s11684-009-0018-5
关键词: free radicals tumor phox cell proliferation cancer therapy
null
《医学前沿(英文)》 2014年 第8卷 第2期 页码 227-235 doi: 10.1007/s11684-014-0327-1
Accelerated senescence is important because this process is involved in tumor suppression and has been induced by many chemotherapeutic agents. The platinum-based chemotherapeutic agent cisplatin displays a wide range of antitumor activities. However, the molecular mechanism of cisplatin-induced accelerated senescence in hepatocellular carcinoma (HCC) remains unclear. In the present study, the growth inhibitory effect of cisplatin on HepG2 and SMMC-7721 cells was detected by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Cellular senescence was then assessed by β-galactosidase assay. Senescence-related factors, including p53, p21, and p16, were evaluated by quantitative reverse transcription-polymerase chain reaction. Reactive oxygen species (ROS) was analyzed by flow cytometry. Our results revealed that cisplatin reduced the proliferation of HepG2 and SMMC-7721 cells in a dose- and time-dependent manner. Senescent phenotype observed in cisplatin-treated hepatoma cells was dependent on p53 and p21 activation but not on p16 activation. Furthermore, cisplatin-induced accelerated senescence depended on intracellular ROS generation. The ROS scavenger N-acetyl-L-cysteine also significantly suppressed the cisplatin-induced senescence of HepG2 and SMMC-7721 cells. In conclusion, our results revealed a functional link between intracellular ROS generation and cisplatin-induced accelerated senescence, and this link may be used as a potential target of HCC.
关键词: reactive oxygen species senescence cisplatin hepatocellular carcinoma
Jun Song, Yeping Huang, Wenjian Zheng, Jing Yan, Min Cheng, Ruxing Zhao, Li Chen, Cheng Hu, Weiping Jia
《医学前沿(英文)》 2018年 第12卷 第6期 页码 697-706 doi: 10.1007/s11684-018-0655-7
Oxidative stress induced by free fatty acid aggravates endothelial injury, which leads to diabetic cardiovascular complications. Reduction of intracellular oxidative stress may attenuate these pathogenic processes. The dietary polyphenol resveratrol reportedly exerts potential protective effects against endothelial injury. This study determined whether resveratrol can reduce the palmitic acid (PA)-induced generation of reactive oxygen species (ROS) and further explored the underlying molecular mechanisms. We found that resveratrol significantly reduced the PA-induced endothelial ROS levels in human aortic endothelial cells. Resveratrol also induced endothelial cell autophagy, which mediated the effect of resveratrol on ROS reduction. Resveratrol stimulated autophagy via the AMP-activated protein kinase (AMPK)-mTOR pathway. Taken together, these data suggest that resveratrol prevents PA-induced intracellular ROS by autophagy regulation via the AMPK-mTOR pathway. Thus, the induction of autophagy by resveratrol may provide a novel therapeutic candidate for cardioprotection in metabolic syndrome.
关键词: resveratrol reactive oxygen species AMPK mTOR autophagy
null
《医学前沿(英文)》 2018年 第12卷 第3期 页码 289-300 doi: 10.1007/s11684-017-0550-7
Silver-containing preparations are widely used in the management of skin wounds, but the effects of silver ions on skin wound healing remain poorly understood. This study investigated the effects of silver ions (Ag+) on the proliferation of human skin keratinocytes (HaCaT) and the production of intracellular reactive oxygen species (ROS). After treating HaCaT cells with Ag+and/or the active oxygen scavenger N-acetyl cysteine (NAC), cell proliferation and intracellular ROS generation were assessed using CCK-8 reagent and DCFH-DA fluorescent probe, respectively. In addition, 5-bromo-2-deoxyUridine (BrdU) incorporation assays, cell cycle flow cytometry, and proliferating cell nuclear antigen (PCNA) immunocytochemistry were conducted to further evaluate the effects of sub-cytotoxic Ag+ concentrations on HaCaT cells. The proliferation of HaCaT cells was promoted in the presence of 10−6 and 10−5 mol/L Ag+ at 24, 48, and 72 h. Intracellular ROS generation also significantly increased for 5–60 min after exposure to Ag+. The number of BrdU-positive cells and the presence of PCNA in HaCaT cells increased 48 h after the addition of 10−6 and 10−5 mol/L Ag+, with 10−5 mol/L Ag+ markedly increasing the cell proliferation index. These effects of sub-cytotoxic Ag+ concentrations were repressed by 5 mmol/L NAC. Our results suggest that sub-cytotoxic Ag+ concentrations promote the proliferation of human keratinocytes and might be associated with a moderate increase in intracellular ROS levels. This study provides important experimental evidence for developing novel silver-based wound agents or dressings with few or no cytotoxicity.
关键词: ionic silver human keratinocyte cell proliferation reactive oxygen species active oxygen scavenger NAC
Relationship between reactive oxygen species and sodium-selenite-induced DNA damage in HepG2 cells
ZOU Yunfeng, NIU Piye, GONG Zhiyong, YANG Jin, YUAN Jing, WU Tangchun, CHEN Xuemin
《医学前沿(英文)》 2007年 第1卷 第3期 页码 327-332 doi: 10.1007/s11684-007-0063-x
Annemie Bogaerts, Maksudbek Yusupov, Jamoliddin Razzokov, Jonas Van der Paal
《化学科学与工程前沿(英文)》 2019年 第13卷 第2期 页码 253-263 doi: 10.1007/s11705-018-1786-8
关键词: plasma medicine cancer treatment computer modelling cell membrane reactive oxygen and nitrogen species
Association of gene variants with juvenile amyotrophic lateral sclerosis
《医学前沿(英文)》 doi: 10.1007/s11684-023-1005-y
关键词: TRMT2B amyotrophic lateral sclerosis mitochondrial complex I tRNA methylation reactive oxygen species
Visible light induces bacteria to produce superoxide for manganese oxidation
《环境科学与工程前沿(英文)》 2023年 第17卷 第2期 doi: 10.1007/s11783-023-1619-y
● Term of manganese-oxidizing microorganisms should be reconsidered.
关键词: Mn(II) oxidation Manganese-oxidizing bacteria Reactive oxygen species Mn(III/IV) oxides
Effects of cultivation strategies on the cultivation of Chlorella sp. HQ in photoreactors
Xiaoya Liu, Yu Hong, Peirui Liu, Jingjing Zhan, Ran Yan
《环境科学与工程前沿(英文)》 2019年 第13卷 第5期 doi: 10.1007/s11783-019-1162-z
关键词: Chlorella sp. HQ Cultivation strategy lipids Nitrogen removal Phosphorus removal Reactive oxygen species
《农业科学与工程前沿(英文)》 2021年 第8卷 第3期 页码 447-459 doi: 10.15302/J-FASE-2021399
Crop rotations are widely used because they can significantly reduce the incidence of pests and diseases. The interactions between non-host roots and pathogens may be key in the inhibition of soilborne pathogens in crop rotations. Interactions between fennel (Foeniculum vulgare) roots/root exudates and Phytophthora nicotianae were investigated because of the known allelopathy between fennel and tobacco (Nicotiana tabacum). The effects of the key compounds in the fennel rhizosphere on the mycelial growth and zoospore behavior of P. nicotianae were assessed. The roots of fennel attracted P. nicotianae zoospores and inhibited their motility and the germination of cystospores, with some cystospores rupturing. 4-ethylacetophenone, vanillin and N-formylpiperidine were consistently identified in the fennel rhizosphere and were found to interfere with the infection of P. nicotianae, especially vanillin. Hyphae treated with these compounds produced more abnormal branches and accumulated reactive oxygen species. These interspecific interactions between non-host roots and pathogens were found to be an important factor in the inhibition by fennel of infection by P. nicotianae.
关键词: fennel and tobacco rotation infection behavior Phytophthora nicotianae reactive oxygen species vanillin
《化学科学与工程前沿(英文)》 2023年 第17卷 第12期 页码 2101-2113 doi: 10.1007/s11705-023-2361-5
关键词: ursolic acid antibacterial activities reactive oxygen species apoptosis
Virender K. Sharma, Xin Yu, Thomas J. McDonald, Chetan Jinadatha, Dionysios D. Dionysiou, Mingbao Feng
《环境科学与工程前沿(英文)》 2019年 第13卷 第3期 doi: 10.1007/s11783-019-1122-7
Antibiotic-resistant bacteria and antibiotic resistance genes are in water bodies. UV/chlorination method is better to remove ARGs than UV or chlorination alone. Research on UV/hydrogen peroxide to eliminate ARGs is forthcoming. UV-based photocatalytic processes are effective to degrade ARGs.
关键词: Antibiotic resistance bacteria Advanced oxidation processes Disinfection Reactive chlorine species Sulfate radicals Reactive oxygen species
《化学科学与工程前沿(英文)》 2021年 第15卷 第6期 页码 1524-1536 doi: 10.1007/s11705-021-2106-2
关键词: Ce–Zr–Cu–O CO oxidation reducible copper species oxygen vacancy cooperative effect
Review on design and evaluation of environmental photocatalysts
Xin Li, Jun Xie, Chuanjia Jiang, Jiaguo Yu, Pengyi Zhang
《环境科学与工程前沿(英文)》 2018年 第12卷 第5期 doi: 10.1007/s11783-018-1076-1
Fundamentals on the photocatalytic degradation were systematically summarized. Charge carrier dynamics for the photocatalytic degradation were reviewed. Adsorption and photodegradation kinetics of reactants were highlighted. The mechanism aspects, including O2 reduction, reactive oxidation species and key intermediates were also addressed. Selectivity and stability of semiconductors for photodegradation were clarified.
关键词: Photocatalytic degradation Environmental remediation Charge carrier dynamics Reactive oxygen species O2 reduction
标题 作者 时间 类型 操作
Biotoxicity evaluation of zinc oxide nanoparticles on bacterial performance of activated sludge at COD, nitrogen
期刊论文
Reactive oxygen species generation is essential for cisplatin-induced accelerated senescence in hepatocellular
null
期刊论文
Resveratrol reduces intracellular reactive oxygen species levels by inducing autophagy through the AMPK-mTOR
Jun Song, Yeping Huang, Wenjian Zheng, Jing Yan, Min Cheng, Ruxing Zhao, Li Chen, Cheng Hu, Weiping Jia
期刊论文
concentrations of ionic silver promote the proliferation of human keratinocytes by inducing the production of reactiveoxygen species
null
期刊论文
Relationship between reactive oxygen species and sodium-selenite-induced DNA damage in HepG2 cells
ZOU Yunfeng, NIU Piye, GONG Zhiyong, YANG Jin, YUAN Jing, WU Tangchun, CHEN Xuemin
期刊论文
Plasma for cancer treatment: How can RONS penetrate through the cell membrane? Answers from computer modeling
Annemie Bogaerts, Maksudbek Yusupov, Jamoliddin Razzokov, Jonas Van der Paal
期刊论文
Effects of cultivation strategies on the cultivation of Chlorella sp. HQ in photoreactors
Xiaoya Liu, Yu Hong, Peirui Liu, Jingjing Zhan, Ran Yan
期刊论文
INTERFERENCE BY NON-HOST PLANT ROOTS AND ROOT EXUDATES IN THE INFECTION PROCESSES OF PHYTOPHTHORA NICOTIANAE
期刊论文
Discovery of novel ursolic acid derivatives as effective antimicrobial agents through a ROS-mediated apoptosis mechanism
期刊论文
Elimination of antibiotic resistance genes and control of horizontal transfer risk by UV-based treatment of drinking water: A mini review
Virender K. Sharma, Xin Yu, Thomas J. McDonald, Chetan Jinadatha, Dionysios D. Dionysiou, Mingbao Feng
期刊论文
Cooperative effect between copper species and oxygen vacancy in CeZrCuO catalysts for carbon monoxide
期刊论文